Of the need to reconcile discrepancies between two different reference equations for combined single-breath DLNO-DLCO in systemic sclerosis

Systemic sclerosis (SSc) is a chronic disease of the connective tissue with an estimated prevalence of 5.8 per 100 000 in a multiethnic population living in Europe [1]. The disease mechanisms are highly complex, affecting multiple organs, including the pulmonary system. Severe pulmonary complications include SSc-associated interstitial lung disease (ILD) and pulmonary hypertension (PH), which are also associated with premature mortality [2, 3]. Early diagnosis and monitoring of pulmonary complications by spirometry, body plethysmography and pulmonary diffusing capacity are critical to lung health in SSc patients [4, 5].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research