Increased pain sensitivity but normal pain modulation in adolescents with migraine

Inhibitory pain modulation has been reported to be deficient in adults across different types of chronic pain, including migraine. To determine whether a similar phenomenon occurs in youth, we performed a quantitative sensory testing investigation in adolescents with migraine (N = 19). These patients were compared to healthy adolescents with (Fam-His; N = 20) or without (Healthy; N = 29) a family history of migraine (eg, first-degree relative with migraine). Subjects were first familiarized with the stimuli and visual analogue rating scales using graded noxious stimuli (0°C, 43-49°C range). These data were used to explore potential pain sensitivity differences between the groups. Pain inhibition was assessed by conditioned pain modulation (CPM), which used both suprathreshold heat pain (heat CPM) and pressure pain thresholds (pressure CPM) as the test stimuli before and during cold-water immersion (8°C). In response to the graded heat stimuli, Fam-His participants reported higher pain intensity ratings compared with patients with migraine, who in turn reported higher pain intensity ratings than the healthy controls (F = 3.6, [df = 2, 459], P = 0.027). For heat and pressure CPM, there was no significant group difference in the magnitude of CPM responses. Thus, adolescents with migraine and healthy adolescents have similar inhibitory pain modulation capability, despite having marked differences in pain sensitivity. Although Fam-His participants are asymptomatic, the...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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We report a 46-year old woman affected by migraine, anxiety and mild depressive mood (MSQ score: 24; BDI score: 34; VAS score: 8) that partially improved with pregabalin treatment (VAS: 5). Laboratory findings documented low serum levels of vitamin D (25-hydroxy-vitamin D: 12 ng/mL; normal range: 20-100 ng/mL; 1-25 di-hydroxy-vitamin D: 19 ng/mL, normal range: 25-66 ng/mL). The treatment with 10,000 UI vitamin D during pregabalin therapy induced an improvement of clinical symptoms (pain, anxiety and depression) and of the quality of life. This case report suggest that in chronic migraine patient with anxiety and mild mood ...
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
A 16 -year-old girl with a history of bilateral head pain, diagnosed as chronic migraines was evaluated in the neurology clinic. Examination revealed decreased sensation to light touch and pinprick on the right side of the face, in the distribution of all three branches of the trigeminal nerve, and extending into the mid-scalp. There were no symptoms or signs of raised intracranial pressure, and the rest of the neurological examination was unremarkable. Magnetic Resonance Imaging of the brain revealed an expansile and enhancing mass in the right Meckel ’s cave extending into the right prepontine cistern, with moderat...
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Visual Diagnosis Source Type: research
Migraine is a highly disabling disease characterized by recurrent pain.Despite an intensive effort, mechanisms of migraine pathophysiology, still represent an unsolved issue. Evidences from both animals and humans studies suggest that migraine is characterized by hyperresponsivity or hyperexcitability of sensory cortices, especially the visual cortex. This phenomenon, in turn, may affect multisensory processing. Indeed, migraineurs present with an abnormal, reduced, perception of the Sound-induced Flash Illusion (SiFI), a crossmodal illusion that relies on optimal integration of visual and auditory stimuli by the occipital...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Swatting a Fly Without Killing It May Cause It Pain for the Rest of Its Life, Study Finds — Gizmodo Barely missing a fatal slap at a bothersome fly might be a headache for both of you, according to new research from scientists at the University of Sydney. They say they’ve found evidence that insects are capable of feeling chronic pain after an injury, much like we do. What’s more, studying why... apple.news Treatment algorithms? CBT?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Saw palmetto (Serenoa repens) is a small palm tree native to the southeastern United States. Currently, saw palmetto is used as a dietary supplement for urinary symptoms associated with benign prostatic hyperplasia (BPH), as well as for chronic pelvic pain, decreased sex drive, migraine, hair loss, and other conditions.According to a 2017 systematic review of 22 studies, saw palmetto was one of the most frequently used herbal supplement.
Source: NCCAM Featured Content - Category: Complementary Medicine Authors: Source Type: news
Abstract Acupuncture has been increasingly used as an integrative or complementary therapy for pain. It is well-tolerated with little risk of serious adverse effects. Traditional acupuncture and nontraditional techniques, such as electroacupuncture and dry needling, often result in reported pain improvement. Multiple factors may contribute to variability in acupuncture's therapeutic effects, including needling technique, number of needles used, duration of needle retention, acupuncture point specificity, number of treatments, and numerous subjective (psychological) factors. Controlled trials have been published on...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
This study reviewed the medical records of adults with inadequately controlled CM from 7 private neurology practices in Australia who, beginning in March 2014, received PBS-subsidized onabotulinumtoxinA per product labelling for the first time. The primary effectiveness measure was the percentage of patients achieving a response defined by 50% or greater reduction in headache days from baseline after 2 treatment cycles. Additional data were recorded in the case report form when available and included demographics, clinical characteristics, headache severity and frequency, Headache Impact Test (HIT-6) score, medication use,...
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
ConclusionsWe identified a positive association between persistent LBP and primary headache disorders. The quality of the review findings is limited by diversity of populations, study designs and uncertainly about headache and LBP definitions.Trial registrationPROSPERO 2018CRD42018086557.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
Abstract The allergic airway diseases, including chronic rhinosinusitis (CRS), asthma, allergic bronchopulmonary mycosis (ABPM) and many others, comprise a heterogeneous collection of inflammatory disorders affecting the upper and lower airways and lung parenchyma that represent the most common chronic diseases of humanity. In addition to their shared tissue tropism, the allergic airway diseases are characterized by a distinct pattern of inflammation involving the accumulation of eosinophils, type 2 macrophages, innate lymphoid cells type 2 (ILC2), IgE-secreting B cells, and T helper type 2 (Th2) cells in airway t...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
ConclusionThe surgical management for trigeminal neuralgia in association with CMT is still an understudied subject, and yet microvascular decompression is a suitable technique for this condition, because it may resolve the vascular decompression by the placement of teflon and may also liberate adhesions if present.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
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