Influence of fixation method and duration of archiving on immunohistochemical staining intensity in embryonic and fetal tissues.

CONCLUSION: To the best of our knowledge, the influence that the duration of tissue block archiving has on IHC positivity in human embryo and fetal tissue material has not yet been studied. Although the causes of the IHC positivity decline in archived tissue blocks are not well understood, a possible decrease in IHC over time should be considered, particularly in retrospective studies.
PMID: 31005572 [PubMed - as supplied by publisher]

Source: Annals of Anatomy - April 17, 2019 Category: Anatomy Authors: Tauber Z, Stetkova I, Cizkova K Tags: Ann Anat Source Type: research