Identification of novel Adenosine Deaminase 2 gene variants and varied clinical phenotype in pediatric vasculitis

ConclusionOur findings support previous reports that DADA2 has extensive genotypic and phenotypic variability. We suggest that screeningADA2 among children with vasculitic rash, UCV, PAN, or unexplained early ‐onset CNS disease with systemic inflammation may enable an earlier diagnosis of DADA2.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatology - April 21, 2019 Category: Rheumatology Authors: Kristen M Gibson, Kimberly A Morishita, Paul Dancey, Paul Moorehead, Britt Dr ögemöller, Xiaohua Han, Jinko Graham, Robert EW Hancock, Dirk Foell, Susanne Benseler, Rashid Luqmani, Rae S M Yeung, Susan Shenoi, Marek Bohm, Alan M Rosenberg, Tags: Full Length Source Type: research