Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration.

Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Int J Mol Sci. 2019 Apr 17;20(8): Authors: Jantrapirom S, Lo Piccolo L, Yamaguchi M Abstract Ubiquitin-like/ubiquitin-associated proteins (UbL-UbA) are a well-studied family of non-proteasomal ubiquitin receptors that are evolutionarily conserved across species. Members of this non-homogenous family facilitate and support proteasomal activity by promoting different effects on proteostasis but exhibit diverse extra-proteasomal activities. Dysfunctional UbL-UbA proteins render cells, particularly neurons, more susceptible to stressors or aging and may cause earlier neurodegeneration. In this review, we summarized the properties and functions of UbL-UbA family members identified to date, with an emphasis on new findings obtained using Drosophila models showing a direct or indirect role in some neurodegenerative diseases. PMID: 30999567 [PubMed - in process]
Source: Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Sci Source Type: research