Copy number variation of bovine SHH gene is associated with body conformation traits in Chinese beef cattle.

Copy number variation of bovine SHH gene is associated with body conformation traits in Chinese beef cattle.
J Appl Genet. 2019 Apr 17;:
Authors: Liu M, Li B, Shi T, Huang Y, Liu GE, Lan X, Lei C, Chen H
Abstract
Sonic Hedgehog (Shh) regulates many key developmental processes during vertebrate limb development, fat formation, and skeletal tissue regeneration. Current whole genome sequencing data have identified a copy number variation mapping to bovine Sonic Hedgehog gene (SHH-CNV). The object of this study was to characterize the SHH-CNV distributions in 648 individuals from 11 Chinese cattle populations and further to investigate the associations of the copy number changes with gene expression and cattle growth traits. The SHH-CNV showed a high variance within Chinese indigenous yellow cattle. Compared to yak and dairy cattle, the beef cattle like Luxi and Xianan breed had significantly higher median copy numbers, suggesting the diversity of SHH-CNV in beef cattle selections. The negative correlation of SHH-CNV with SHH transcriptional level in adult adipose tissue (P < 0.01) indicated the dosage effects of SHH-CNV related to bovine fat formation. Association analysis of SHH-CNV and body size traits was conducted in five breeds. The results revealed that the copy number gain type of SHH-CNV exhibited significantly better chest depth in 24 months old Qinchuan cattle, and better body weight, body length, and chest girth in 18...

Source: J Appl Genet - April 16, 2019 Category: Genetics & Stem Cells Authors: Liu M, Li B, Shi T, Huang Y, Liu GE, Lan X, Lei C, Chen H Tags: J Appl Genet Source Type: research