458 The antidiabetic agent metformin prevents the development of psoriasis via inhibition of caspase-1 inflammasome

Psoriasis is a systemic inflammatory disease that associatated with comorbidities including type 2 diabetes. Metformin is utilized as a first-line antidiabetic agent for the treatment of type 2 diabetes. Although metformin reportedly exhibits anti-inflammatory effects in various cells, the mechanism in the skin has not been determined. To reveal this, we examined whether metformin treatment affected the development of psoriasis in imiquimod (IMQ) -induced mouse psoriasis model. Oral treatment of metformin (20 mg/kg, daily) showed a significant decrease in ear swelling and epidermal hyperplasia.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research