461 Depletion of the microbiome using broad-spectrum antibiotic cocktail improves the psoriasiform phenotype via attenuation of TNF α and IL-23-IL-17A in three psoriasis mouse models

The gut microbiome plays a critical role in immune development and can impact inflammation in distant organs in rheumatoid arthritis, uveitis and alopecia areata. The potential contributions of the microbiota to psoriasis remains unclear. To test the hypothesis that the microbiota contributes to psoriasiform skin inflammation, we treated KC-Tie2, IL-17C+ and KLK6+ psoriasiform mouse models with a broad-spectrum antibiotic cocktail (ampicillin, neomycin, vancomycin). 5-week old psoriasis mice (n=6-14/grp) were exposed to either regular drinking water or the antibiotic cocktail for ∼ 6 weeks, and then the skin examined.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research