820 m6A mRNA demethylase FTO regulates tumorigenicity and response to anti-PD-1 immunotherapy in melanoma

Analogous to epigenetic regulation of gene expression through the reversible DNA and histone modifications, post-transcriptional N6-methyladenosine (m6A) methylation of adenosine residues in mRNA as well as lncRNA provides an additional layer of regulation that may alter mRNA metabolism and gene expression. Recently, m6A RNA methylation research was revived by the discovery of the fat mass- and obesity-associated protein (FTO) as the first RNA demethylase, implying that m6A RNA methylation is a reversible and dynamic modification and may have critical biological functions.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: S. Yang, J. Wei, Y. Cui, P. Shah, Y. Deng, A. Aplin, Z. Lu, C. He, Y. He Tags: Pigmentation and Melanoma Source Type: research