Mechanisms Linking White Matter Lesions, Tract Integrity and Depression in Alzheimer's Disease

Late-life depression is one of the most common mental illnesses in the aging population and its prevalence is exacerbated in those with dementia.1 Onset of depressive symptoms in late-life is precipitated by risk factors including cerebrovascular disease, old age, vulnerable genotypes, low socioeconomic status and stressful life events.2-4 Of these risks, the most studied has been cerebrovascular disease, which has been proposed by the vascular depression hypothesis to predispose, precipitate and perpetuate late-life depression by altering cerebral white matter.

Source: The American Journal of Geriatric Psychiatry - April 17, 2019 Category: Geriatrics Authors: Chathuri Yatawara, Daryl Lee, Kok Pin Ng, Russell Chander, Debby Ng, Fang Ji, Hee Youn Shim, Saima Hilal, Narayanaswamy Venketasubramanian, Christopher Chen, Juan Zhou, Nagaendran Kandiah Tags: Regular Research Article Source Type: research