A novel electrochemical sensor for the detection of oxidative stress and cancer biomarker (4-nitroquinoline N-oxide) based on iron nitride nanoparticles with multilayer reduced graphene nanosheets modified electrode

Publication date: 15 July 2019Source: Sensors and Actuators B: Chemical, Volume 291Author(s): Umamaheswari Rajaji, Akilarasan Muthumariyappan, Shen-Ming Chen, Tse-Wei Chen, R. Jothi RamalingamAbstractHerein, a novel iron nitride nanoparticles (Fe2N NPs) decorated reduced graphene oxide (rGOS) nanocomposite have been designed through a solvothermal method and followed by a nitridation process. After then, as-synthesized Fe2N NPs@rGOS was characterized by HRTEM, FESEM, XPS, XRD, and EIS. Furthermore, the nanocomposite modified SPCE (screen-printed carbon electrode) shows excellent electrochemical sensing performance towards biomarker of 4-nitroquinoline N-oxide (4-NQO) with fast detection. 4-NQO is one of the important cancer biomarker. Moreover, the fabricated sensor showed a wide linear window for 4-NQO between 0.05–574.2 μM and nanomolar detection limit (9.24 nM). Further, the as-prepared Fe2N NPs@rGOS/SPCE has been applied to the determination of 4-NQO in human blood and urine samples with recoveries close to 100%.
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research