Gene therapy cures infants suffering from ‘bubble boy’ immune disease

After years of heartbreaking setbacks, researchers say they can restore immune systems in SCID babies.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news

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Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): F. Zhang, S. Gao, X. Yang
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 20 February 2020Source: Materials Chemistry and PhysicsAuthor(s): Bashir Mosayyebi, Mahsa Imani, Leila Mohammadi, Abolfazl Akbarzadeh, Nosratollah Zarghami, Mahdi Edalati, Effat Alizadeh, Mohammad RahmatiAbstractCyanogenic glycosides are defined as natural herbal toxins which are found in more than 2000 plant species and most of them consumed by humans. These nitrile-containing compounds do not present toxic effects in intact form while they produce toxic cyanide following enzymatic digestion. Therefore, over-consuming of these compounds can lead to cyanide poisoning. On the other hand, s...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Cancer Gene Therapy, Published online: 21 February 2020; doi:10.1038/s41417-020-0168-9Reviewer Recognition
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
Stem cell populations become damaged and dysfunctional with age. Some of this is issues with the stem cells themselves, and some of this results from problem with the signaling environment and function of the stem cell niche. Which of these factors is more important likely varies by stem cell population. Among the best studied of stem cell types, the evidence suggests that muscle stem cells remain capable in old age, but become ever more quiescent, while hematopoietic stem cells become damaged and dysfunctional, unable to perform. Hematopoietic stem cells reside in the bone marrow and are responsible for generating blood a...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Agreement gives BIA Separations access to proprietary technology to better preserve integrity, infectivity and potency of immunoaffinity-purified viral vectors for gene therapy
Source: The Scientist - Category: Science Tags: The Scientist The Marketplace Source Type: news
To compare the efficacies between intratumoral herpes simplex virus-thymidine kinase (HSV-TK)/ganciclovir (GCV) gene therapy and oncolytic virotherapy for image-guided radiofrequency hyperthermia (RFH)-enhanced treatment of orthotopic liver cancer.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Traditional Poster Source Type: research
In conclusion, non‐viral gene therapy to rBCECs leads to protein secretion and signifies a method for NPC2 to target cells inside the CNS otherwise inaccessible due to the pres ence of the BBB. However, obtaining high transfection efficiencies is crucial in order to achieve sufficient therapeutic effects.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
(Oregon State University) Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they need to be inside cells.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 19 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Ashley Boice, Lisa Bouchier-HayesAbstractMembers of the caspase family of proteases play essential roles in the initiation and execution of apoptosis. These caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis. Many conventional cancer therapies induce apoptosis to remove the cancer cell by engagin...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Authors: Park JE, Yun SA, Roh EY, Yoon JH, Shin S, Ki CS Abstract Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by progressive proximal muscle weakness and atrophy. Given the recent introduction of gene therapies, knowledge of the SMA carrier frequency in various populations has become important for developing screening programs for this disease. In total, 1,581 anonymous DNA samples from an umbilical cord blood bank were tested for SMN1 and SMN2 gene copies using a multiplex ligation-dependent probe amplification assay. Twenty-nine of the 1,581 newborns [1.83%; 95% confidence interv...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
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