Cancers, Vol. 11, Pages 559: New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer

Cancers, Vol. 11, Pages 559: New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer Cancers doi: 10.3390/cancers11040559 Authors: Khaled Bidet Breast cancer is the most common cancer and leading cause of cancer death among women worldwide, encompassing a wide heterogeneity of subtypes with different clinical features. During the last two decades, the use of targeted therapies has emerged in clinical research in order to increase treatment efficiency, improve prognosis and reduce recurrence. However, the triple negative breast cancer (TNBC) subtype remains a clinical challenge, with poor prognosis since no therapeutic targets have been identified. This aggressive breast cancer entity lacks expression of oestrogen receptor (ER) and progesterone receptor (PR), and it does not overexpress human epidermal growth factor receptor 2 (HER2). The major reason for TNBC poor prognosis is early therapeutic escape from conventional treatments, leading to aggressive metastatic relapse. Metastases occur after an epithelial-mesenchymal transition EMT of epithelial cells, allowing them to break free from the primary tumour site and to colonize distant organs. Cancer-associated EMT consists not only of acquired migration and invasion ability, but involves complex and comprehensive reprogramming, including changes in metabolism, expression levels and epigenetic. Recently, many studies have considered epigenetic alterations as the prima...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research