PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation.

CONCLUSION: This study proposed the upregulation of PIM1 by IL-6 contributed to breast cancer cell aggressiveness and targeting PIM1 or c-myc could be novel approaches for breast cancer treatment.
PMID: 30989585 [PubMed - as supplied by publisher]

Source: Breast Cancer - April 14, 2019 Category: Cancer & Oncology Authors: Gao X, Liu X, Lu Y, Wang Y, Cao W, Liu X, Hu H, Wang H Tags: Breast Cancer Source Type: research