Cancers, Vol. 11, Pages 551: Genetic Variants as Predictive Markers for Ototoxicity and Nephrotoxicity in Patients with Locally Advanced Head and Neck Cancer Treated with Cisplatin-Containing Chemoradiotherapy (The PRONE Study)

In conclusion, we showed prospectively that in LAHNC patients genetic variants in ACYP2 are significantly associated with clinically determined ototoxicity. Validation studies are necessary to prove the added value for individualized treatments plans in these patients.

Source: Cancers - April 16, 2019 Category: Cancer & Oncology Authors: Chantal M. Driessen Janneke C. Ham Maroeska te Loo Esther van Meerten Maurits van Lamoen Marina H. Hakobjan Robert P. Takes Winette T. van der Graaf Johannes H. Kaanders Marieke J.H. Coenen Carla M. van Herpen Tags: Article Source Type: research