Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users.

CONCLUSIONS: The novel hydromorphone prodrug ASAL-HM produced marked reductions in hydromorphone exposure and abuse-related effects following IN administration compared with HM. ASAL-HM has desirable molecular features for incorporation into putative abuse-deterrent immediate-release and extended-release hydromorphone products. PMID: 30986302 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30986302?dopt=Abstract

Source: Methods of Information in Medicine - April 14, 2019 Category: Information Technology Authors: Guenther S, Mickle TC, Barrett AC, Smith A, Braeckman R, Kelsh D, Vince B Tags: Pain Med Source Type: research