Synovial C-reactive protein features high negative predictive value but is not useful as a single diagnostic parameter in suspected periprosthetic joint infection (PJI)

The numbers of total joint arthroplasties (TJA) have steadily increased over the last decade, and concomitantly, there has been an increase in the absolute numbers of periprosthetic joint infections (PJI).1 For clinicians, it is crucial to distinguish between septic and aseptic causes of joint pain because treatment options differ regarding antibiotic therapies and surgical procedures.2 Several societies published guidelines for the diagnosis of PJIs. Most commonly, the guideline of the Infectious Diseases Society of America (IDSA)3 and the adapted Musculoskeletal Infection Society (MSIS) guideline by the consensus meeting 2013 are currently used.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research