The key microRNAs regulated the development of non-small cell lung cancer by targeting TGF- β-induced epithelial-mesenchymal transition.

CONCLUSIONS: miRNA-330-3p and miRNA-205 were changed the most in the process of canceration in NSCLC. Furthermore, miR-330-3p promoted cell invasion and metastasis in NSCLC probably by promoting EMT and miR-205 could restrain NSCLC was likely by suppressing EMT. PMID: 30968775 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research

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Markus Hartl* and Rainer Schneider Center of Molecular Biosciences (CMBI), Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed in the growth cones of nerve cells where they are involved in signal transmission and cytoskeleton organization. Although their primary structures are unrelated, these signaling proteins share several structural properties like fatty acid modification, and the presence of cationic effector domains. GAP43, MARCKS, and BASP1 bind to cell membrane phospholipids, a process reversibly regulate...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Awasthi S, Singhal SS, Singhal J, Nagaprashantha L, Li H, Yuan YC, Liu Z, Berz D, Igid H, Green WC, Tijani L, Tonk V, Rajan A, Awasthi Y, Singh SP Abstract In previous studies, we found that 2'-hydroxyflavonone (2HF), a citrus flavonoid, inhibits the growth of renal cell carcinoma in a VHL-dependent manner. This was associated with the inhibition of glutathione S-transferases (GSTs), the first step enzyme of the mercapturic acid pathway that catalyzes formation of glutathione-electrophile conjugates (GS-E). We studied 2HF in small cell (SCLC) and non-small cell (NSCLC) lung cancer cell lines for sensitivit...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Lung cancer is the leading cause of cancer-related death both in USA and accounts for 1.8 million new cases (13.0% of the all cancers) cases each year in worldwide [1,2]. Epithelial lung cancer is classified into two main groups: small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is the most common subtype of lung cancer and accounts for more than 80% of the total lung cancer occurrence [3]. NSCLC comprises squamous-cell carcinoma (SCC), adenocarcinoma (ADC), and large-cell lung cancer (LCC) [4].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Opinion statementA decade after the discovery of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (EML4-ALK) rearrangements in non-small cell lung cancer (NSCLC), several inhibitors have gained regulatory approval, and their sequential use has deferred platinum-based chemotherapy to later lines of therapy. Nevertheless, although most ALK-driven tumors dramatically respond to ALK TKIs , all patients ultimately develop drug-resistant disease. Analysis of post-progression biopsy samples has provided invaluable insight into the mechanisms of resistance, now informing on subsequent therapeutic ...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
Abstract Epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the response of non-small cell lung cancer (NSCLC) with EGFR-mutant patients. However, these patients inevitably come cross acquired resistance to EGFR-TKIs. The transformation of lung adenocarcinoma to small cell lung cancer (SCLC) following treatment with EGFR-TKIs is rare, which leads to resistance to EGFR-TKIs. The present case concerns a case of a 38-year-old man presenting with cough and dyspnea. Radical resection was performed and confirmed an EGFR exon 21 L858R lung adenocarcinoma. However, the patient ...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
Kaixian Zhang, Qianqian YuanJournal of Cancer Research and Therapeutics 2016 12(7):131-137Lung cancer continues to be a major health problem and the most common cancer-related mortality worldwide with about 80%–85% patients suffering from nonsmall cell lung cancer (NSCLC). More than 80% of NSCLC cases are often diagnosed as advanced stage and harbor epidermal growth factor receptor (EGFR) activating mutation. Although great success in initial response to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) are found in EGFR-mutant NSCLC patients, acquired resistance usually occurs on the continuous treatment. Here...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
In spite of recent therapeutics advances and early detection, lung cancer is still the leading cause of cancer-associated deaths worldwide. The five-year survival rates for its two major subtypes, small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) are estimated to be 6% and 18%, respectively. This high mortality is due to its aggressive nature even when detected at an early stage. Besides its aggressive nature and tendency for early metastasis, another feature of lung cancer is the inactivation of the retinoblastoma protein (Rb) that is observed in both lung cancer subtypes. NSCLC exhibits Rb inactivation...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Systems Biology Source Type: research
Contributors : Jill E Larsen ; Luc Girard ; John D MinnaSeries Type : Expression profiling by arrayOrganism : Homo sapiensUsing an in vitro model for malignant transformation of human bronchial epithelial cells (HBECs) we have found epithelial-to-mesenchymal transition (EMT) and expression of the EMT-transcription factor ZEB1 are early and critical events. Specifically, we found preexisting oncogenic mutations in TP53 and KRAS were required for HBECs to engage EMT machinery in response to microenvironmental (serum/TGF β) or specific oncogenetic (MYC) EMT-inducing factors, which induce EMT through distinct TGFβ-de...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Conclusion Notch3 signaling in lung carcinoma is dependent on cell type. In SCLC, Notch3 behaves as a tumor suppressor pathway, while in NSCLC it acts as a tumor-promoting pathway.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
There is increasing agreement that minimally invasive biomarkers to monitor patients receiving targeted therapies have significant potential to facilitate personalized medicine. The rarity and heterogeneity of CTCs make them a technically demanding source of biomarkers but one that holds great promise as the technical challenges are met. Marker independent technology platforms are in development which will better assess CTC subpopulations, but none so far have been fully validated for clinical trial use and treatment decision-making. CTC enumeration with CellSearch (EpCam and cytokeratin positive CTCs) has prognostic signi...
Source: Molecular Cancer Therapeutics - Category: Cancer & Oncology Authors: Tags: Biomarkers: Oral Presentations - Invited Abstracts Source Type: research
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