Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia

Publication date: Available online 8 April 2019Source: Leukemia Research ReportsAuthor(s): Meiyu Chen, Jie Liu, Wei Qin, Qian Wang, Ri Zhang, Hongying ChaoAbstractThe natural history of primary hypereosinophilia remains poorly defined, given the underlying disease heterogeneity. Recently, targeted NGS helps to establish clonality in a subset of patients with hypereosinophilia. We first reported the clonal evolution in a long-term follow-up patient with hypereosinophilia. This case initially presented with chronic eosinophilic leukemia, not otherwise specified (CEL-NOS), successively transformed to myelodysplastic syndromes(MDS) and acute myeloid leukemia(s-AML). We identified three mutations at CEL-NOS phase, five and seven mutations at MDS and s-AML stages, respectively. Our data illustrate the clonal dynamic process associated with disease evolution from CEL-NOS to s-AML.
Source: Leukemia Research Reports - Category: Hematology Source Type: research