Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system.

CONCLUSION: A novel mTLE-NHP model was induced by one-time intra-hippocampal and intra-amygdalar KA injection, with detectable SE and SRS. Severe hippocampal atrophy, neuronal ultrastructural damage, BBB disruption, neuronal loss and gliosis were confirmed in this model, with widespread limbic system damage, which are similar to the pathology of mTLE patients. PMID: 30954527 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30954527?dopt=Abstract

Source: Brain Research Bulletin - April 3, 2019 Category: Neurology Authors: Chen Y, Zhu G, Shi L, Liu D, Zhang X, Liu Y, Yuan T, Du T, Zhang J Tags: Brain Res Bull Source Type: research