Synthesis of benzophenones and in vitro evaluation of their anticancer potential in breast and prostate cancer cells.

Synthesis of benzophenones and in vitro evaluation of their anticancer potential in breast and prostate cancer cells. ChemMedChem. 2019 Apr 04;: Authors: Saidi L, Rocha DHA, Talhi O, Bentarzi Y, Nedjar-Kolli B, Bachari K, Almeida Paz FA, Helguero LA, Silva AM Abstract Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2-hydroxybenzophenones via 1,4-conjugate addition/ intramolecular cycloaddition/ dehydration of nitromethane on the key intermediate chromones. Structures were extensively studied by 2-dimensional Nuclear Magnetic Resonance (2D-NMR) and single-crystal X-ray diffraction studies. Their cytotoxicity was evaluated in vitro, in two breast cancer cell lines (MDA-MB-231 and T47-D) and one prostate cancer cell lines (PC3). The most potent compound exhibited good cytotoxic effect against the three cancer cell lines (IC50 values ranging from 12.09 to 26.49 µM) and induced cell cycle retardation only on prostate cancer cells, which suggests that it may exert cell-type specific effects. PMID: 30950201 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research