Susceptibility profile of Candida rugosa (Diutina rugosa) against antifungals and compounds of essential oils

Publication date: Available online 5 April 2019Source: Journal de Mycologie MédicaleAuthor(s): A. Ludwig, F.P.K. de Jesus, V. Dutra, S.L. Cândido, S.H. Alves, J.M. SanturioAbstractCandida rugosa (recently reclassified Diutina rugosa) is an emerging pathogen affecting humans and animals. Candida resistance to existing drugs is an important factor to be monitored, as well as the need of researching alternatives to conventional antifungals. Here, we evaluated the in vitro effects of some antifungals and major components of essential oils by the broth microdilution method (CLSI M27-A3) against fifteen C. rugosa strains from animals isolated and molecular identificated. The results showed MIC90 of: 0.125 μg/mL to ketoconazole and voriconazole, 0.25 μg/mL to micafungin, 0.5 μg/mL to anidulafungin, 1 μg/mL to caspofungin, 2 μg/mL to amphotericin B, itraconazole and flucytosin, 8 μg/mL to fluconazole, 16 μg/mL to nystatin and>128 μg/mL to terbinafine. The compounds carvacrol (MIC90 320 μg/mL), thimol (MIC90 320 μg/mL) and cinnamaldehyde (MIC90 160 μg/mL) demonstrated antifungal activity against the samples tested.
Source: Journal of Medical Mycology - Category: Biology Source Type: research