Effects of Spaceflight on Cardiovascular Physiology and Health

This article reviews the knowledge gained in human experiments in the past half century of spaceflight, and summarizes our knowledge on the effects of short- and long-duration microgravity exposure on cardiovascular physiology and functioning, including fluid redistribution, autonomic reflexes, cardiac parameters, orthostatic intolerance, arrhythmias, aerobic capacity, and cardiac atrophy. This review also discusses current countermeasures for risk reduction during spaceflight, as well as future directions in cardiovascular research in space.
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research

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Conditions:   Cancer;   Cardiac Disease;   Metabolic Syndrome;   Arrhythmia;   Heart Diseases Intervention:   Other: No interventions are planned Sponsor:   European Georges Pompidou Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A 41-year-old man came to the emergency department because of the sudden onset of palpitations and dizziness. It started when he was celebrating the championship of his soccer team in a pub nearby. As shown in Figure  1A, during the registration of a 12-lead electrocardiogram (ECG) in the first heart aid clinic, a regular wide QRS tachycardia suddenly accelerated accompanied by a drop in blood pressure. The emergency physician terminated the arrhythmia by electrical cardioversion. Figure 1B shows the ECG there after.
Source: Heart Rhythm - Category: Cardiology Authors: Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 lead ECG Source Type: research
ConclusionsOur findings suggest lower scar heterogeneity (mean entropy) is associated with successful ATP whereas higher scar heterogeneity is associated with more aggressive VAs unresponsive to ATP requiring shock therapy which may be due to inability of the paced wavefront to propagate through scar and terminate the VA circuit.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: DEVICES Source Type: research
In this study, we propose using bidirectional long short-term memory (LSTM)-based deep recurrent neural networks (DRNN) through late-fusion to develop a real-time system for ECG-based biometrics identification and classification. We suggest a preprocessing procedure for the quick identification and noise reduction, such as a derivative filter, moving average filter, and normalization. We experimentally evaluated the proposed method using two public datasets: MIT-BIH Normal Sinus Rhythm (NSRDB) and MIT-BIH Arrhythmia (MITDB). The proposed LSTM-based DRNN model shows that in NSRDB, the overall precision was 100%, recall was ...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
ConclusionsRVOT VAs often originate from voltage-transitional zone, and automatic annotation of LAT usually located at later high-amplitude far-field potential. Lumipoint algorithms could improve the accuracy of LAT automatic annotation, and it was plausible to ablate RVOT VAs just according to the automatically annotated BEAS-lu.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
AbstractEbstein anomaly comprises approximately 1% of all congenital heart diseases. It occurs when the tricuspid valve fails to properly delaminate from the right ventricle, resulting in a clinical spectrum of abnormal tricuspid valve morphology and right ventricular dysfunction. Due to the anatomy of the tricuspid valve and right ventricle, as well as associated right- and left-sided pathology, patients are at risk for both right and left ventricular failure and the associated symptoms of each. Ebstein patients are also at risk for atrial arrhythmias, due to the atrial enlargement intrinsic to the anatomy, as well as the...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Mutations in the genes encoding the highly conserved Ca2+-sensing protein calmodulin (CaM) cause severe cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia or long QT syndrome and sudden cardiac death. Most of the identified arrhythmogenic mutations reside in the C-terminal domain of CaM and mostly affect Ca2+-coordinating residues. One exception is the catecholaminergic polymorphic ventricular tachycardia–causing N53I substitution, which resides in the N-terminal domain (N-domain). It does not affect Ca2+ coordination and has only a minor impact on binding affinity toward Ca2+ and on...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
Depression is a frequent and debilitating comorbidity that affects heart failure (HF) patients. Up to 30% of HF patients suffer from depression and even more have depressive symptoms. Moreover, depression carries a risk for HF, especially in high ‐risk groups, and is significantly associated with worse quality of life and clinical outcomes. The pathophysiology of depression and HF is poorly understood, but both diseases share several mechanisms and risk factors, including dysregulation of platelet reactivity, inflammation, neuroendocrine f unction, arrhythmias, high‐risk behaviours, and social factors. Current HF guide...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Review Source Type: research
AbstractPurposeCompared with open thoracotomy, minimally invasive esophagectomy (MIE) methods, such as transhiatal or thoracoscopic esophagectomy, likely have lower morbidity. However, the relationship between intraoperative fluid management and postoperative complications after MIE remains unclear. Thus, we investigated the association of cumulative intraoperative fluid balance and postoperative complications in patients undergoing MIE.MethodsThis single-center retrospective cohort study examined patients undergoing thoracoscopic esophagectomy for esophageal cancer in the prone position. Postoperative complications includ...
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
Salas-Pacheco JL Abstract Sudden cardiac arrest (SCA) and sudden death (SD) continues to be a global public health problem, although the true incidence is unknown, it is estimated that they are responsible for 30% of cardiac origin mortality and may represent 20% of total mortality in adults. Unfortunately, the majority of cases occur in the general population, at the out-of-hospital level, in homes and in people who were not known to have heart disease. Although the majority of SCD victims are considered to be of cardiac origin and more frequent ischemic, it is not possible to rule out other causes only with the...
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
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