[Pharmacokinetic and pharmacodynamic modelling in paediatric drug development with a focus on physiology-based pharmacokinetic simulations].

[Pharmacokinetic and pharmacodynamic modelling in paediatric drug development with a focus on physiology-based pharmacokinetic simulations]. Z Evid Fortbild Qual Gesundhwes. 2019 Mar 29;: Authors: Läer S Abstract Pharmacokinetic and pharmacodynamic models are mandatory for dosing and the safe use of drugs in the paediatric population. Different modelling methods allow for the development of dosing regimens for children requiring only a small number of blood samples or none at all. The medicines regulatory authorities recommend using these methods for paediatric drug development programs. Taking sildenafil as an example, the least invasive method of physiology-based pharmacokinetic simulation for the development of dosing regimens in the paediatric population is presented. PMID: 30935788 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30935788?dopt=Abstract

Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - April 4, 2019 Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research