Fellowship to further international research links in Huntington's disease

(University of Plymouth) Dr. Shouqing Luo, Associate Professor in the University's Institute of Translational and Stratified Medicine, received the Newton Advanced Fellowship from the Royal Society, in partnership with the UK Academy of Medical Sciences and the National Nature Science Foundation of China.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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The pathogenic effect of mutant HTT (mHTT) which causes Huntington disease (HD) are not restricted to nervous system. Such phenotypes include aberrant immune responses observed in the HD models. However, it is still unclear how this immune dysregulation influences the innate immune response against pathogenic infection. In the present study, we used transgenic Drosophila melanogaster expressing mutant HTT protein (mHTT) with hemocyte-specific drivers and examined the immune responses and hemocyte function. We found that mHTT expression in the hemocytes did not affect fly viability, but the numbers of circulating hemocytes ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
HUNTINGTON, W.Va. - A West Virginia federal judge on Sept. 25 denied a disability claimant's motion to enforce a settlement without a deduction for applicable tax withholding after determining that the plan at issue and the Internal Revenue Service require that taxes be withheld from the settlement amount because the settlement clearly qualifies as replacement wages for tax purposes (Noel Jordan v. AT&T Integrated Disability Service Center Disability Plan, et al., No. 18-94, S.D. W.Va., 2019 U.S. Dist. LEXIS 164015).
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - Category: Medical Law Source Type: news
To identify the characteristics and prevalence of mild cognitive impairment in patients with motor-manifest Huntington's disease (HD) and to propose a new mild cognitive impairment (HD-MCI) classification for HD.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
Paul Farrell vows to make the opioid pill industry pay for what happened to Huntington.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Hypothalamic pathology is a well-documented feature of Huntington's disease (HD) and is believed to contribute to circadian rhythm and habitual sleep disturbances. Currently, no therapies exist to combat hypothalamic changes, nor circadian rhythm and habitual sleep disturbances in HD.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
Neuroinflammation is a condition characterized by the elaboration of proinflammatory mediators within the central nervous system. Neuroinflammation has emerged as a dominant theme in contemporary neuroscience due to its association with neurodegenerative disease states such as Alzheimer's disease, Parkinson's disease and Huntington's disease. While neuroinflammation often is associated with damage to the CNS, it also can occur in the absence of neurodegeneration, e.g., in association with systemic infection.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Abstract Huntington's disease (HD) is caused by CAG repeat expansion within the HTT gene, with the dysfunction and eventual loss of striatal medium spiny neurons a notable feature. Since medium spiny neurons receive high amounts of synaptic input, we hypothesised that this vulnerability originates from an inability to sustain presynaptic performance during intense neuronal activity. To test this hypothesis, primary cultures of either hippocampal or striatal neurons were prepared from either wild-type mice or a knock-in HD mouse model which contains 140 poly-glutamine repeats in the huntingtin protein (httQ140/Q140...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
BOSTON (CBS) – A Boston resident has the city’s first confirmed case of the measles since 2013. The Public Health Commission announced Wednesday that others may have been exposed at a number of locations in the South End, Fenway and Back Bay neighborhoods. Doctors diagnosed the case on Sunday. Health officials released the following lists of locations in Boston and times where the person could have exposed others: Friday, October 4th 1:30pm to 4:30pm Render Coffee, 563 Columbus Avenue, South End Friday, October 4th 2:30pm to 4:45pm Cafe Madeleine, 517 Columbus Avenue, South End Friday, October 4th 6:30pm to 9:3...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Measles Source Type: news
Condition:   Huntington Disease Interventions:   Genetic: rAAV5-miHTT;   Procedure: Imitation surgery Sponsor:   UniQure Biopharma B.V. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Huntington SF, Hoag JR, Wang R, Zeidan AM, Giri S, Gore SD, Ma X, Gross CP, Davidoff AJ Abstract BACKGROUND: Provider experience, or clinical volume, is associated with improved outcomes in many complex healthcare settings. Despite increased complexity of anticancer therapies, studies evaluating physician-level experience and cancer treatment outcomes are lacking. METHODS: A population-based study was conducted of older adults (aged ≥66 years) diagnosed with B-cell non-Hodgkin's lymphoma in 2004 through 2011 using SEER-Medicare data. Analysis focused on outcomes in patients receiving rituximab, the ...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
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