Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice

Conclusion: This first PET investigation with longitudinal TSPO and amyloid PET together with terminal cognitive testing in an AD mouse model indicates that continuing microglial response seems to impart preserved cognitive performance.

Source: Journal of Nuclear Medicine - March 31, 2019 Category: Nuclear Medicine Authors: Focke, C., Blume, T., Zott, B., Shi, Y., Deussing, M., Peters, F., Schmidt, C., Kleinberger, G., Lindner, S., Gildehaus, F.-J., Beyer, L., von Ungern-Sternberg, B., Bartenstein, P., Ozmen, L., Baumann, K., Dorostkar, M. M., Haass, C., Adelsberger, H., Her Tags: Basic Source Type: research