miR-1246 as a therapeutic target in oral submucosa fibrosis pathogenesis.
CONCLUSION: MiR-1246 is not only critical to the maintenance of oral stemness but also important to the activation of myofibroblasts. Our results showed that miR-1246 is positively associated with the type I collagen, which may be a downstream effector of miR-1246 and responsible for the fibrosis effect on fBMFs.
PMID: 30928188 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - Category: General Medicine Authors: Liu CM, Liao YW, Hsieh PL, Yu CH, Chueh PJ, Lin T, Yang PY, Yu CC, Chou MY Tags: J Formos Med Assoc Source Type: research