Virus-like particle vaccines for poliovirus types 1, 2, and 3 with enhanced thermostability expressed in insect cells.

In this study, PV1, PV2, and PV3 virus-like particles with enhanced thermostability (PV-sVLPs) were produced in large quantities by using a baculovirus expression vector system (BEVS). Mice immunized with PV-sVLPs generated antibodies with strong PV-neutralizing response. In addition, splenocytes collected from immunized mice expressed high levels of IFN-γ, IL-2, GM-CSF, IL-5, and IL-10 upon PV-sVLPs stimulation. These data suggest that PV-sVLPs can serve as vaccines against PV infection.
PMID: 30922699 [PubMed - as supplied by publisher]

Source: Vaccine - March 24, 2019 Category: Allergy & Immunology Authors: Xu Y, Ma S, Huang Y, Chen F, Chen L, Ding D, Zheng Y, Li H, Xiao J, Feng J, Peng T Tags: Vaccine Source Type: research