Reduced Ischemic Lesion Growth with Heparin in Acute Ischemic Stroke

Objective: The role of heparin in acute ischemic stroke is controversial. We investigated the effect of heparin on ischemic lesion growth. Methods: Data were analyzed on nonthrombolyzed ischemic stroke patients in whom diffusion-weighted imaging (DWI)/perfusion-weighted imaging (PWI) MRI was performed less than 12hours of last known well and showed a PWI-DWI lesion mismatch, and who underwent follow-up neuroimaging at least 4days after admission. Lesion growth was assessed by (1) absolute lesion growth and (2) percentage mismatch lost (PML).

Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Eva A. Rocha, Ruijun Ji, Hakan Ay, Zixiao Li, Ethem Murat Arsava, Gisele S. Silva, Alma Gregory Sorensen, Ona Wu, Aneesh B. Singhal Source Type: research