Targeting the transforming growth factor- β pathway: a novel mechanism of ulipristal acetate action against uterine fibroids

Uterine fibroids are benign monoclonal neoplasms of the myometrium that represent the most common tumor in reproductive-age women worldwide. Their prevalence is approximately 70% –80% in women by the age of 50 years. Histopathology analysis shows increased smooth muscle cells, collagen, proteoglycans, and fibronectin in a disorganized matter (1). This abnormal proliferation causes anatomic distortion leading to the signs and symptoms present in uterine fibroids, which inc lude abnormal uterine bleeding, pelvic pain, and reproductive dysfunction (impaired implantation, infertility, and spontaneous abortion).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research