Nanovaccine boosts immunity in sufferers of metabolic syndrome
(Cornell University) A new class of biomaterial developed by Cornell researchers for an infectious disease nanovaccine effectively boosted immunity in mice with metabolic disorders linked to gut bacteria - a population that shows resistance to traditional flu and polio vaccines.
Data from a federal program designed to compensate people harmed by vaccines shows how rare it is for someone to claim they were hurt after getting vaccinated.
In this study, we performed 2D-DIGE and MALDI-TOF/TOF MS to analyze differentially expressed proteins between HeLa and invasive HeLa-I5 cells..Key findingsAccording to our proteomics data, 68 differentially expressed proteins between the HeLa and HeLa-I5 cells were identified. One of these differentially expressed proteins, Progesterone receptor membrane component 1 (PGRMC1), was selected as a candidate for further studies. To correlate the role of PGRMC1 with cellular migration and cancer progression, small interfering RNA (siRNA) was used to knockdown the expression of PGRMC1. Similar function of PGRMC1 was also observed...
In this study, groups of chickens were vaccinated twice intramuscularly at 14-day interval either with plasmid DNA encoding F protein gene of NDV or with recombinant F protein alone or with plasmid DNA and boosted with the recombinant F protein and compared with birds that were vaccinated with live NDV vaccine. The immune response was evaluated by indirect ELISA, lymphocyte transformation test, virus neutralization test, cytokine analysis, immunophenotyping of peripheral blood mononuclear cells, and protective efficacy study against virulent NDV challenge virus infection. Chickens in prime-boost group developed a higher le...
Pigs are important livestock and comprehensive understanding of their immune responses in infections is critical to improve vaccines and therapies. Moreover, similarities between human and swine physiology suggest that pigs are a superior animal model for immunological studies. However, paucity of experimental tools for a systematic analysis of the immune responses in pigs represent a major disadvantage. To evaluate the pig as a biomedical model and additionally expand the knowledge of rare immune cell populations in swine, we established a multicolor flow cytometry analysis platform of surface marker expression and cellul...
Children with asthma and recurrent wheezing can safely receive the nasal spray influenza vaccine, a large study found.Medscape Medical News
VBI Vaccines Inc said on Monday a late-stage study was unsuccessful in showing two doses of its hepatitis B vaccine were as effective as three doses of an older vaccine from GlaxoSmithKline, sending its shares plunging 66%.
According to data from the World Health Organization, 41,000 measles cases were reported from January to June 2018 across 53 European countries
Condition: Pediatric Recurrent Brain Tumor Interventions: Biological: Personalized neoantigen DNA vaccine; Device: TDS-IM System; Procedure: Peripheral blood draw Sponsors: Washington University School of Medicine; Children's Discovery Institute Not yet recruiting
Condition: Human Papilloma Virus (HPV) Interventions: Behavioral: Text Message; Behavioral: PostCard; Behavioral: Standard of Care; Behavioral: Motivational Interview Sponsor: University of Florida Completed