Dosimetric and chemical characteristics of Fricke gels based on PVA matrices cross-linked with glutaraldehyde.

Dosimetric and chemical characteristics of Fricke gels based on PVA matrices cross-linked with glutaraldehyde.
Phys Med Biol. 2019 Mar 26;:
Authors: Lazzeri L, Marini A, Cascone MG, d'Errico F
Abstract
Fricke gel radiochemical sensors based on various matrices have been studied for decades as 3D dosimeters for radiotherapy. Despite their many appealing features, progressive aging and blurring of the signal have prevented the widespread use of these dosimeters, so far. We have addressed these shortcomings and hereby present our development of a Fricke gel based on a chemically cross-linked PVA matrix. We investigated the influence of several parameters of the polymeric matrix on sensitivity, diffusion coefficient and spontaneous oxidation of the proposed gel dosimeter. Based on these findings, we optimized the gel compositions. Our new gel formulation combines transparency, high sensitivity and simple production method, typical of gels based on natural polymers, with low diffusion coefficient and slow spontaneous oxidation typical of PVA gels made by freezing-thawing.
PMID: 30913547 [PubMed - as supplied by publisher]

Source: Physics in Medicine and Biology - March 25, 2019 Category: Physics Authors: Lazzeri L, Marini A, Cascone MG, d'Errico F Tags: Phys Med Biol Source Type: research