Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase.

This article is protected by copyright. All rights reserved. PMID: 30903663 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Eur J Immunol Source Type: research

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In this study, we characterized sirtuin in the white koji fungus, Aspergillus kawachii, to examine their role on regulation of amylolytic enzymes and citric acid productions during the solid-state culture (koji). Characterization of rice-koji made using five putative sirtuin gene disruptants indicated that they are involved in amylolytic activity and acidity of rice koji; especially the sirD disruptant showed lower levels of α-amylase activity and citric acid production per mycelial weight in the koji compared the control strain. In addition, the sirD disruptant also showed a change in mycelial pigmentation, higher s...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Aspergillus kawachii Source Type: research
Publication date: Available online 13 June 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Yasir Mehmood Khan, Hira Munir, Zahid AnwarAbstractUrease is one of the important enzymes secreted by microorganisms in the soil, but can also be produced by microbial fermentation. The present study aimed to explore optimum conditions for maximum urease enzyme production from wheat straw by applying a statistical approach, response surface methodology (RSM), under the solid-state fermentation process. Eight different local strains of Aspergillus niger were screened for the production of urease enzyme. Fermentation ...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: October 2019Source: Protein Expression and Purification, Volume 162Author(s): Ye Ke, Meng-yao Wei, Yu-tong Fu, Yan-mei Zhu, Xuan-lin ZhanAbstractThe Aspergillus niger AS3.350 protease gene (pepD) was successfully cloned and expressed in Pichia pastoris KM71. The rPepD activity was 331.5 U/ml, and the optimum temperature and pH were 45 °C and 8–9 respectively. In addition, enzyme activity was significantly inhibited by PMSF, EDTA, Mg2+, Fe2+ and Zn2+ ions, and stimulated by Ca2+ which selectively bound to the T302 and D323 residues. Mutation in either or both of the residues inhibited rPepD exp...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Changxing Qi, Qun Zhou, Weixi Gao, Mengting Liu, Chunmei Chen, Xiao-Nian Li, Yongji Lai, Yuan Zhou, Dongyan Li, Zhengxi Hu, Hucheng Zhu, Yonghui ZhangAbstractSpiroterreusnoids A–F, six undescribed spiro-dioxolane-containing adducts bearing 3,5-dimethylorsellinic acid-based meroterpenoid and 2,3-butanediol moieties were isolated from the endophytic fungus Aspergillus terreus Thom from Tripterygium wilfordii Hook. f. (Celastraceae). The structures of these adducts were established by spectroscopy, single-crystal X-ray diffraction, and experime...
Source: Phytochemistry - Category: Chemistry Source Type: research
This study aimed to investigate the dose-response and pharmacology of a range of single doses of nebulised ensifentrine (RPL554), an inhaled dual phosphodiesterase (PDE) 3/4 inhibitor in patients with asthma.MethodsIn this randomised, placebo-controlled, double-blind crossover study, patients received single nebulised doses of ensifentrine 0.4, 1.5, 6 and 24 mg, salbutamol 2.5 and 7.5 mg, and placebo. Eligible patients were adults with asthma, pre-bronchodilator forced expiratory volume in 1 s (FEV1) 60–90% predicted and ≥1.5 L, with post-salbutamol FEV1 increase ≥15%. The co-primary objectives were pea...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Publication date: Available online 14 June 2019Source: Academic PediatricsAuthor(s): Mindy Ross, Sande Okelo, Alex Bui
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
Abstract The current climate changes in the form of global warming are one of the leading threats to agricultural crops (including soybean and sunflower). To enable the crops to cope with the heat stress, innovative steps are needed to be taken as soon as possible. Fungal endophytes are known to secrete secondary metabolites that promote the growth of host plants under stress conditions. Therefore, we have isolated endophytic fungus from Euphorbia indica (a wild desert plant) and tested it for plant growth promoting activities. The culture filtrate of the fungal strains exhibited the presence of secondary metaboli...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conditions:   Asthma;   Asthma in Children Intervention:   Behavioral: Self-management Intervention Package Sponsors:   Johns Hopkins University;   Asociación Benéfica Prisma;   Hospital Nacional Cayetano Heredia;   American Thoracic Society Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Asthma in Children Intervention:   Sponsor:   Gazi University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Aspergillosis threatens endangered kakapo, “the world’s fattest parrot”Fri, 06/14/2019 - 11:40News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
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