Bufadienolides from the skins of Bufo melanosticus and their cytotoxic activity

Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Lingjie Meng, Nian Jiang, Changyan Yu, Sanhua Li, Zeli Chun, Xinting Zhu, Changwei Song, Yi Xiao, Jing Hui, Ying Qin, Yun LiuAbstractThree new bufadienolides, (2β,5β,14β)-2,5,14-trihydroxy-bufa-20,22-dienolide (1), (3α,16β)-3,16-dihydroxy-bufa-14,20,22-trienolide (2) and (3β,5β,16α)-3,5,16-trihydroxy-bufa-14,20,22-trienolide (3), together with three known analogs (4-6), were isolated from the aqueous extracts of the skins of Bufo melanosticus. Their structures were determined by spectroscopic studies, including HR-ESIMS and NMR data analyse. In the preliminary assay, all the above mentioned compounds showed cytotoxic activity against the carcinoma cell lines Bel-7402, HO-8910 and HCT-116, with IC50 values ranging from 0.01 to 24.07 μM, consistent with the practical application of toad skin and cinobufacini (Hua Chan Su).Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research