Severe occupational asthma: Insights from a multicenter European cohort

ConclusionsThis study indicates that a substantial proportion of subjects with OA experience severe asthma and identifies potentially modifiable risk factors for severe OA that should be targeted in order to reduce the adverse impacts of the disease.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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Ulrik Stervbo1†, Toralf Roch2†, Timm H. Westhoff1, Ludmyla Gayova3, Andrii Kurchenko3, Felix S. Seibert1‡ and Nina Babel1,2*‡ 1Center for Translational Medicine, Medical Department I, Marien Hospital Herne, University Hospitals of the Ruhr-University of Bochum, Herne, Germany 2Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany 3Department of Bioorganic and Biological Chemistry, Bogomolets National M...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Analysis of the pleiotropic effects of IL-33 on multiple immunological cells (macrophages, mastocytes), as well as neurological cells of medulla oblongata, dorsal root ganglion, antigen-induced arthritis system, carrageen, and formalin, shows that this alarmin plays curtail, yet not fully known role in mediating inflammation, especially in chronic inflammatory pulmonary diseases such as asthma, COPD, and OSA. Taken into consideration the engagement in this process, in particular of mastocytes and their secretion of CXCL2, 4, 8, and other cytokines, there is no doubt regarding the etiopathogenic role of IL-33 in...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study also revealed adenosine as a novel danger-associated molecular pattern (DAMP), responsible for initiating helminth-induced type-2 responses, through activation of ILC2s. Additional receptors reported to be highly expressed by ILC2s and required for their expansion and function include the tumor necrosis factor (TNF)-receptor superfamily member DR3 (TNFRSF25) and the IL-9R. In the absence of TL1A ligation to DR3, there is significantly reduced ILC2 expansion, type-2 cytokine production and N. brasiliensis expulsion (74), whereas IL-9R signaling was required for ILC2 accumulation, expulsion of N. brasiliensis and...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion There are numerous microbial communities inhabited in the human body, which is critical to human health. The relationship between human microbiome and diseases received much attention from both medical and bioinformatics community recently. However, traditional methods to detect their association is costly and labor-intensive. Thus, we proposed here a new computational model called NBLPIHMDA to infer potential microbe-disease associations. NBLPIHMDA first combined known microbe-disease associations in HMDAD and the Gaussian interaction profile kernel similarity to construct disease similarity network and microb...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Human microbiome is normal flora for humans, which has been proved to be of symbiotic relationship with humans and harmless to humans. If the microbes that breed in the human body become “unhealthy,” it will definitely affect the host's physical condition. People are continuing to explore the pathologic relationship between microorganisms and the human body through high-throughput sequencing technologies and analysis systems. However, it is a pity that their pathogenesis cannot be fully understood as yet. Considering that relying only on conventional experimental methods is time-consuming an...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
The inner-city is a well-established and well-studied location that includes children at high risk for high asthma prevalence and morbidity. A number of intrinsic and extrinsic risk factors contribute to asthma in inner-city populations. This review seeks to explore these risk factors and evaluate how they contribute to increased asthma morbidity. Previous literature has identified risk factors such as race and ethnicity, prematurity, obesity, and exposure to aeroallergens and pollutants. Environmental and medical interventions aimed at individual risk factors and specific asthma phenotypes have contributed to improved out...
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
It’s hardly news that the gastrointestinal tract is important to human health: It transports food from the mouth to the stomach, converts it into absorbable nutrients and stored energy, and shuttles waste back out of the body. If you don’t properly nourish yourself, you don’t live. It’s that simple. But in recent years, scientists have discovered that the GI system has an even bigger, more complex job than previously appreciated. It’s been linked to numerous aspects of health that have seemingly nothing to do with digestion, from immunity to emotional stress to chronic illnesses, including can...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Research Source Type: news
Studies evaluating the association between abdominal obesity and asthma yielded conflict results. Whether abdominal obesity is positively associated with asthma remains unclear.
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
AbstractBackgroundHalf of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype. A data-driven approach applied to the same subjects may allow a more useful classification compared to the hypothesis-driven one.AimTo compare previously defined hypothesis-driven with newly derived data-driven asthma phenotypes, identified by latent class analysis (LCA), in adults with current asthma from NHANES 2007 –2012.MethodsAdults ( ≥ 18 years) with current asthma from the NHANES were include...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
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