Successful treatment of XDR-TB patient in Tanzania: report of the first XDR-TB patient.

We present the first case with confirmed extensive drug-resistant TB in Tanzania in a patient who had prior exposure to anti-TB drugs and a history of imprisonment in South Africa. The addition of bedaquiline to the treatment regime resulted in positive to negative sputum conversion. After a total of 30 months on treatment he was declared cured, remaining clinically stable and culture-negative throughout the follow-up. Close monitoring is important in managing drug-resistant TB cases, and good surveillance is required to detect drug-resistant TB to prevent further transmission. PMID: 30885056 [PubMed - as supplied by publisher]
Source: Tropical Doctor - Category: Tropical Medicine Authors: Tags: Trop Doct Source Type: research

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Publication date: Available online 20 August 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Amy Oreskovic, Norman D. Brault, Nuttada Panpradist, James J. Lai, Barry R. LutzUrine cell-free DNA (cfDNA) is a valuable noninvasive biomarker for detecting cancer mutation, diagnosing infectious disease (eg, tuberculosis), monitoring organ transplantation, and prenatal screening. Conventional silica DNA extraction does not efficiently capture urine cfDNA, which is dilute (ng/mL) and highly fragmented (30 to 100 nt). The clinical sensitivity of urine cfDNA detection increases with decreasing target length, motivating us...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
We describe a pediatric intensive care unit nurse with latent TB infection who developed hemoptysis and a lung infiltrate concerning for active TB. Her evaluation and contact investigation were facilitated by our institution's command center. Although TB was ultimately ruled out, this case tested our team-based care in response to a suspected high-consequence pathogen.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
The objective of this study was to determine the prevalence of malaria/TB coinfection among bacteriologically confirmed adult TB patients at a national TB treatment centre in Uganda. Using a cross-sectional study design we enrolled 363 bacteriologically confirmed adult TB patients, and data on demographics and medical history was collected. Blood samples were tested for malaria blood smear, rapid malaria diagnostic test (RDT), complete blood count, haematological film analysis, HIV serology, and CD4+ and CD8+ cell counts. Malaria was defined as either a positive blood smear or RDT. The study participants were mostly male (...
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
This study explores a possible association with tuberculosis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
We report a rare case of concomitant pulmonary TB and leprosy identified in the United States.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Despite the known association between the use of biologic medications and reactivation of latent tuberculosis infection (LTBI) the rate of LTBI among indigent Hispanic psoriatic patients living in the U.S. has not been studied. Little is known about the overall impact LTBI may pose on their treatment of psoriasis and/or psoriatic arthritis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
We present a case of a 48-year-old male who developed patchy hair loss on the scalp and limbs clinically consistent with alopecia areata, two months following re-commencement of HAART.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Publication date: Available online 20 August 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Victoria Howell, Tom BashfordAbstractThe range of infectious diseases encountered while working overseas in resource limited settings varies enormously depending on where in the world one is working, although the majority of low and middle income countries lie within the tropics. Human immunodeficiency virus (HIV), tuberculosis (TB) and malaria are commonly encountered when working in tropical countries and may have an impact upon anaesthesia, either as a direct result of the condition or due to interaction with the ...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: 1 January 2020Source: Materials Chemistry and Physics, Volume 239Author(s): K. Govindaraju, K. Vijai Anand, S. Anbarasu, J. Theerthagiri, S. Revathy, P. Krupakar, G. Durai, M. Kannan, K.S. SubramanianAbstractFacile synthesis of Mg(OH)2 nanomaterials using seaweed Turbinaria ornata is reported herein. X-ray powder diffraction (XRD) analysis infer that crystal structures of Mg(OH)2 nanomaterials exhibit hexagonal brucite structure with thickness and lateral dimension around 7.75 nm and 16.29 nm (measured with Scherrer equation) respectively. FE-SEM images reveal that the flakes like structure were well ...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Abstract The causative agents of zoonotic bovine tuberculosis (bTB), Mycobacterium bovis and M. caprae, are members of the M. tuberculosis complex (MTC). Wildlife such as red deer infected with bTB are often without pathological findings, thus meat thereof may be classified as safe for human consumption. The culturing of MTC is time consuming and inappropriate to be applied with fresh meat and food. Therefore, a rapid method "PMA qPCR" to differentiate living and dead cells of MTC was developed in this study. By treating with 50 μM PMA™ dye, dead M. bovis BCG (≤104 cells/ml meat suspensio...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research
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