Pharmacokinetics: Unique Challenges in Blood Monitoring for Oncology Nurses.
This article will provide an overview of evidence-based approaches to the collection of PK samples, monitoring of PK levels, and the resulting management of patients undergoing PK testing.
METHODS: A case study involving busulfan, an alkylating agent used in the pre-stem cell transplantation setting, will highlight the cross-contamination of samples while a drug is being infused through a central venous catheter with PK sample collection from a proximal peripherally inserted central catheter. The influence of false elevations in drug concentrations on PK-guided dose adjustments will also be emphasized.
FINDINGS: Imprecise blood collections or cross-contamination of samples may lead to inaccurate drug concentration results and, subsequently, undesired low or high drug dosage calculations.
PMID: 30880803 [PubMed - in process]
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Kawedia JD, Kalariya N, Gulbis AM, Andersson BS, Myers AL Tags: Clin J Oncol Nurs Source Type: research
More News: Cancer & Oncology | Central Venous Catheterization | Nurses | Nursing | Stem Cell Therapy | Stem Cells | Study | Transplants