Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers

Publication date: Available online 18 March 2019Source: International Journal of PharmaceuticsAuthor(s): V. Umayangana Godakanda, Heyu Li, Laura Alquezar, Lixiang Zhao, Li-Min Zhu, Rohini de Silva, K.M. Nalin de Silva, Gareth R. WilliamsAbstractThe management of pain and inflammation arising from wounds is essential in obtaining effective healing rates. The application of a wound dressing loaded with an anti-inflammatory drug would enable both issues to be ameliorated, and the aim of this work was to fabricate such a dressing by electrospinning. Fibers comprising ethyl cellulose (EC) and poly(vinyl pyrrolidone) (PVP) loaded with naproxen (Nap) were developed to be used in the early stages of wound care. A family of PVP/EC/Nap systems was prepared by varying the PVP: EC ratio. In all cases, the products of electrospinning comprise non-woven mats of fibers which generally have smooth and cylindrical morphologies. The formulations exist as amorphous solid dispersions, and there appear to be intermolecular interactions between all three components. Adjusting the polymer ratios results in tunable drug release, and formulations have been produced which give zero-order drug release over 20 and 80h. The fiber mats generated in this work thus have great potential to be used as dressings for the treatment of wound pain and inflammation.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research