Diabetes and Chronic Kidney Disease Basics: Part One

An estimated 14.8% of adults have chronic kidney disease (CKD).1 Diabetic kidney disease (DKD) is classified according to the presence of microalbuminuria or macroalbuminuria.2 Of the 30 million US individuals with diabetes, those who met any criteria for DKD is estimated at 26.2%. Using 2010 census data, this translates to a prevalence of approximately 8.2 million people with any DKD, including 4.6 million people with albuminuria, 1.9 million people with macroalbuminuria, 4.5 million people with reduced estimated glomerular filtration rate (eGFR), and 0.9 million people with severely reduced eGFR.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Patient Education Source Type: research

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With'a host'of treatments in the pipeline, fatty liver disease no longer plays second fiddle to diabetes-related cardiovascular disease and chronic kidney disease, says researcher Gregory Nichols.Medscape Diabetes &Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Expert Column Source Type: news
Abstract Extracellular vesicle (EV)-based regenerative therapy has shown promising results in preclinical models of renal disease and might be useful for patients with several forms of chronic kidney disease (CKD). However, individuals with CKD often present with comorbidities, including obesity, hypertension, diabetes, or even metabolic syndrome, which may alter the endogenous characteristics and impair the reparative capacity of stem cells and their daughter EVs. This brief review summarizes evidence of alterations in the morphology, cargo, and function of mesenchymal stem cells (MSCs) and MSC-derived EVs in the...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Publication date: Available online 19 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Subash C. Gupta, Nikee Awasthee, Vipin Rai, Srinivas Chava, Venugopal Gunda, Kishore B. ChallagundlaAbstractThe regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, H...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
Chronic Kidney Disease (CKD) is strongly associated with an increased risk of stroke, small vessel disease, and vascular dementia. Common vascular factors for stroke, such as hypertension, diabetes, and atrial fibrillation, are more prevalent in CKD patients, accounting for this association. However, factors unique to these patients, such as uraemia, oxidative stress, mineral and bone abnormalities, as well as dialysis-related factors are also believed to contribute to risk. Despite improvements in stroke treatment and survival in the general population, the rate of improvement in patients with CKD, especially those who ar...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Review Source Type: research
Publication date: November 2019Source: Artificial Intelligence in Medicine, Volume 101Author(s): Dunja Vrbaški, Milan Vrbaški, Aleksandar Kupusinac, Darko Ivanović, Edita Stokić, Dragan Ivetić, Ksenija DoroslovačkiAbstractMetabolic Syndrome (MetS) is associated with the risk of developing chronic disease (atherosclerotic cardiovascular disease, type 2 diabetes, cancers and chronic kidney disease) and has an important role in early prevention. Previous research showed that an artificial neural network (ANN) is a suitable tool for algorithmic MetS diagnostics, that includes solely non-invasive, low-cost and...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
ConclusionThe technical considerations for performing a LeFort Colpocleisis include ruling out malignancy prior to surgery, adequate lateral channels for uterine drainage, the use of lidocaine with epinephrine, closure in multiple layers with excellent hemostasis and an aggressive posterior colpoperineorrhaphy.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
The most clinically relevant new aspects of the 2019 version of the ESC Guidelines compared with the previous version published in 2013 relate to:Reclassification of cardiovascular (CV) risk.Individualized blood pressure (BP) targets.New lipid targets relating to severity of CV risk.Recommendations for the use of PCSK9 inhibitors in lipid management.New recommendations regarding the role of aspirin and the novel oral anticoagulants (NOACs) in diabetes.New recommendations for the duration of dual antiplatelet therapy post-ACS in diabetes mellitus (DM).The interpretation of the CV outcome trials in diabetes therapies and the...
Source: European Heart Journal - Category: Cardiology Source Type: research
Metformin, the first choice drug for type 2 diabetes treatment in all stages of therapy, and one of the most widely prescribed anti-hyperglycemic agent worldwide, represents a rare example of an old drug which continues to display new beneficial effects in various fields. However, lactic acidosis (LA) persists as a serious adverse effect. LA incidence is low and is not necessarily determined by the administration of metformin. Unfortunately, the concern for this complication has negatively affected the drug use, particularly in chronic kidney disease, which may impair drug excretion, and in congestive heart failure and chr...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Authors: Salguero MV, Al-Obaide MAI, Singh R, Siepmann T, Vasylyeva TL Abstract Lipopolysaccharide (LPS), a potent endotoxin present in the outer membrane of Gram-negative bacteria, causes chronic immune responses associated with inflammation. In the present study, the association between LPS and the dysbiosis of Gram-negative bacteria in the gut microbiome was determined in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (T2DM-CKD; stages 4 and 5, not on dialysis) compared with healthy individuals. Microbiome diversity was analyzed in patients with T2DM-CKD and healthy controls by sequenci...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Ștefan G, Florescu C, Sabo AA, Stancu S, Mircescu G Abstract Background: We aimed to evaluate the relationship between biopsy-proven kidney lesions, subclinical markers of atherosclerosis and intrarenal resistive index (RRI) in chronic kidney disease (CKD) patients. Methods: This cross-sectional, single-center study prospectively enrolled 44 consecutive CKD patients (57% male gender, 54.1 (95%CI, 49.7-58.6) years, median eGFR 28.1 (15.0-47.7) mL/min) diagnosed by renal biopsy during 6 months in our clinic. RRI, carotid intima-media thickness (IMT), Kauppila score for abdominal aortic calcification ...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
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