Precision and reliability of liver iodine quantification from spectral detector CT: evidence from phantom and patient data

ConclusionsIodine maps from SDCT allow for reliable quantification of iodine content in phantoms; while in patients, rather large differences between repetitive examinations are likely due to differences in biological distribution. This underlines the need for careful clinical interpretation and further protocol optimization.Key Points•Spectral detector computed tomography allows for reliable quantification of iodine in phantoms.•In patients, the offset between repetitive examinations varies by 20%, likely due to differences in biological distribution.•Clinically, iodine maps should be interpreted with caution and should take the intra-individual variability of iodine distribution over time into account.
Source: European Radiology - Category: Radiology Source Type: research