Validation of immunohistochemical tests performed on cytology cell block material: Practical application of the College of American Pathologists & #39; guidelines

This article will outline how an academic center approaches validation of IHC studies performed on cytology cell block specimens using the College of American Pathologists guidelines. A stepwise approach from selection of antibodies to validate followed by building the validation panel and evaluating the stain results for concordance against the gold standard of histology tissue specimen will be described. A rationale for dealing with discordant results and future innovations will conclude the report.

Source: CytoJournal - March 14, 2019 Category: Pathology Authors: Swati Satturwar Renuka Malenie Ann Sutton Ding Dai F Zahra Aly Source Type: research