Chronic myelomonocytic leukemia as a transformation from polycythemia vera

We present a case of PV that progressed to CMML. We demonstrated the CMML clone was most likely derived from PV- JAK2V617F clone, and carried a complex genetic mutations of ASXL1, RUNX1, SRSF2 and TET2, NRAS, KRAS, plus CMML cells were of the classical phenotype CD14+ CD16− by flow cytometry.
Source: Leukemia Research Reports - Category: Hematology Source Type: research