Antidotes against methanol poisoning, a review.

Antidotes against methanol poisoning, a review. Mini Rev Med Chem. 2019 Mar 12;: Authors: Pohanka M Abstract methanol is the simplest alcohol at all. Comparing to ethanol that is fully detoxified by metabolism, methanol become activated to toxic products by enzymes alcohol dehydrogenase and aldehyde dehydrogenase. Paradoxically, the same enzymes convert ethanol up to harmless acetic acid. This review is focused on discussion and overview of literature devoted to methanol toxicology and antidotal therapy. Regarding to the antidotal therapy, three main approaches are presented in the text: 1) ethanol as a competitive inhibitor on alcohol dehydrogenase; 2) use of drugs like fomepizole inhibiting alcohol dehydrogenase; 3) tetrahydrofolic acid and its analogues reacting with formate as a final product of methanol metabolism. All the types of antidotal therapies are described and principles how they protect from toxic sequelae of methanol are explained. PMID: 30864518 [PubMed - as supplied by publisher]
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research