Effect of Particle Deposition Density of Dry Powders on the Results Produced by an In Vitro Test System Simulating Dissolution- and Absorption Rates in the Lungs.

Effect of Particle Deposition Density of Dry Powders on the Results Produced by an In Vitro Test System Simulating Dissolution- and Absorption Rates in the Lungs. Eur J Pharm Biopharm. 2019 Mar 09;: Authors: Malmlöf M, Nowenwik M, Meelich K, Rådberg I, Selg E, Burns J, Mascher H, Gerde P Abstract The surface area of the air/liquid interface in the lungs is substantial, so deposited doses of aerosol medicines per interface surface area when administered via the inhalation route is always quite low. However, in most in vitro systems used for dissolution testing of dry powder inhalables, the dose per surface area is generally much higher. The aim of this study was to investigate in one in vitro lung dissolution system, the DissolvIt, the manner in which the deposited dose per test surface area of drug particles influences the simulated dissolution- and absorption rate. Here we used the dissolution test method DissolvIt to investigate the influence on dissolution behavior by varying the deposited surface density of tested drugs. Dry powders of three different active pharmaceutical ingredients with different solubilities were used; salmeterol, budesonide and fluticasone propionate. It was found that by varying the dose density from 0.23 to 29 µg/cm2 the dissolution- and absorption rate of test particles was affected for all three substances, with decreasing relative dissolution rates above certain dose limits. The effect was much more ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Biopharm Source Type: research