Memantine Induces Reflex Syncope in Elderly Patients With Dementia: Results From the Syncope and Dementia Study (SYD-Study)

Syncope has been diagnosed with increasing frequency in older patients with dementia.1 Recently, SYncope and Dementia Study (SYD Study) demonstrated how the extensive use of hypotensive drugs is involved in the high prevalence of syncope due to orthostatic hypotension ( ≈50%).2,3 However, very few data are available about the effect of psychotropic drugs used for the treatment of dementia and the development of syncope.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Letter to the Editor Source Type: research

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We report here the identification of two GLUT9-interacting proteins, integral membrane protein 2B (ITM2B) and transmembrane protein 85 (TMEM85), isolated from a human kidney cDNA library using the dual-membrane yeast two-hybrid system. ITM2B is a ubiquitously expressed, N-glycosylated transmembrane regulatory protein, involved in familial dementias and retinal dystrophy; the function of TMEM85 is less defined. Using coimmunoprecipitation, we confirmed the physical interaction between ITM2B or TMEM85 and N-terminal GLUT9 isoforms (GLUT9a and GLUT9b) in transfected HEK 293T cells and Xenopus oocytes, wherein ITM2B but not TM...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: Deterioration of swallowing function was confirmed, even in subjects with mild dementia, in addition to development of problems related to food intake.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Americans aren’t sleeping well. Roughly 80% of U.S. adults say they struggle to fall asleep at least one night a week, according to a recent Consumer Reports survey. And research has found that sleep problems are also on the rise among adolescents. While the causes of America’s sleep woes are up for debate, there’s little disagreement about America’s favorite remedy: Melatonin, by far the country’s most-used sleep aid. What is Melatonin? Melatonin is a hormone that plants and animals, including humans, produce naturally. The melatonin sold in over-the-counter pills is synthetic, but chemically...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized anti-oxidants drug safety inflammation medicine melatonin Source Type: news
We report our diagnostic approach of a pair of siblings with psychomotor regression, hypotonia, optic atrophy and auditory neuropathy. The brain magnetic resonance imaging (MRI) showed progressive cerebellar atrophy. Genetic testing of the PLA2G6 confirmed presence of compound heterozygous novel mutations. As the variant c. 196C>T (p.Gln66X) was a truncating variant, it was considered as pathogenic while the variant c. 2249G>A (p. Cys750Tyr) was considered as “likely pathogenic” by bioinformatics analyses. Our patient expands the clinical phenotype of INAD as it described the first South-East Asian patien...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/ One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Telomere loops (t-loops) are formed at the ends of chromosomes in species ranging from humans to worms, plants, and with genetic manipulation, some yeast. Recent in vitro studies demonstrated that transcription of telomeric DNA leads to highly efficient t-loop formation. It was also shown that both DNA termini are inserted into the preceding DNA to generate a highly stable t-loop junction. Furthermore, some telomeric RNA remains present at the junction, potentially acting as a plug to further protect and stabilize the t-loop. Modeling the loop junction reveals two mechanisms by which the canonical chromosomal replication f...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 26 July 2019Source: Progress in NeurobiologyAuthor(s): Camille A. Ju┼║wik, Sienna S. Drake, Yang Zhang, Nicolas Paradis-Isler, Alexandra Sylvester, Alexandre Amar-Zifkin, Chelsea Douglas, Barbara Morquette, Craig S. Moore, Alyson FournierAbstractWhile the root causes for individual neurodegenerative diseases are distinct, many shared pathological features and mechanisms contribute to neurodegeneration across diseases. Altered levels of microRNAs, small non-coding RNAs involved in post transcriptional regulation of gene expression, are reported for numerous neurodegenerative diseases. Yet,...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
AbstractImpaired processing of emotional signals is a core feature of frontotemporal dementia syndromes, but the underlying neural mechanisms have proved challenging to characterize and measure. Progress in this field may depend on detecting functional changes in the working brain, and disentangling components of emotion processing that include sensory decoding, emotion categorization and emotional contagion. We addressed this using functional MRI of naturalistic, dynamic facial emotion processing with concurrent indices of autonomic arousal, in a cohort of patients representing all major frontotemporal dementia syndromes ...
Source: Brain - Category: Neurology Source Type: research
As a medical student, the place I dreaded most was the ward at the children’s hospital where they kept the chronic ventilator patients. Unlike the other floors, where there was shouting and laughter and tears, and all the commotion and turbulence of youth, here it was dark and lifeless and eerie, with no sound except the hum of the ventilators, and the rattle of air being forced through plastic tubes. It was a place of failure and defeat, the desolate aftermath of some vast and tragic battle. An unexpected aftermath of measles My patient was a teenager who had been in a coma for years. His limbs had stubbornly twiste...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Infectious diseases Men's Health Vaccines Women's Health Source Type: blogs
The objective of the current study was to explore the genetic architecture in one of the most important muscle quality attributes, filet firmness in relation to protein content, and identify QTL associated with these traits in a rainbow trout population developed by the USDA/NCCCWA selective breeding program. Materials and Methods Ethics Statement Institutional Animal Care and Use Committee of the United States Department of Agriculture, National Center for Cool and Cold Water Aquaculture (Leetown, WV, United States) specifically reviewed and approved all husbandry practices used in this study (IACUC approval #056). Fi...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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