Pharmaceutical Cocrystal: A Novel Approach to Tailor the Biopharmaceutical Properties of a Poorly Water Soluble Drug.

Pharmaceutical Cocrystal: A Novel Approach to Tailor the Biopharmaceutical Properties of a Poorly Water Soluble Drug. Recent Pat Drug Deliv Formul. 2019 Mar 06;: Authors: Srivastava D, Fatima Z, Kaur CD, Tulsankar SL, Nashik SS Abstract AIM AND BACKGROUND: The present study reports the formation of a cocrystal of candesartan with the coformer methyl paraben,its characterization and determination of its bioavailability.Candesartan is a poorly water soluble drug having an anti-hypertensive activity. The recent patents on the cocrystals of the drugs Progesterone (US9982007B2), Epalrestat (EP2326632B1), Gefitinib (WO2015170345A1), Valsartan(CN102702118B) for enhancement of solubility helped in selection of the drug for this work. METHODS: Candesartan cocrystal was prepared by solution crystallization method.The formation of new crystalline phase was characterized by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) and Powder X-ray Diffraction (PXRD) studies. Saturation solubility studies were carried out in ethanol: water (50:50 % v/v) mixture. The dissolution studies were conducted in 900 ml of phosphate buffer pH 7.4(I.P.) with 0.7% w/w of Tween 20 at 50 rpm, maintained at a temperature of 37±0.5°C in a USP type II dissolution apparatus. The pharmacokinetic behavior of candesartan and its cocrystal was thereof investigated in male Wistar rats. RESULTS: There was 6.94 fold enhancements in the ...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research