The Burden of Childhood Atopic Dermatitis in the Primary Care Setting: A Report from the Meta-LARC Consortium
Background: Little is known about the burden of atopic dermatitis (AD) encountered in US primary care practices and the frequency and type of skin care practices routinely used in children. Objective: To estimate the prevalence of AD in children 0 to 5 years attending primary care practices in the United States and to describe routine skin care practices used in this population. Design: A cross-sectional survey study of a convenience sample of children under the age of 5 attending primary care practices for any reason. Setting: Ten primary care practices in 5 US states. Results: Among 652 children attending primary care practices, the estimated prevalence of ever having AD was 24% (95% CI, 21–28) ranging from 15% among those under the age of 1 to 38% among those aged 4 to 5 years. The prevalence of comorbid asthma was higher among AD participants compared to those with no AD, namely, 12% and 4%, respectively (P
Authors: Jeziorkowska R, Rożalski M, Skowroński K, Samochocki Z Abstract Introduction: Positive skin prick tests (SPT) results with protein allergens are the minor Hanifin and Rajka's atopic dermatitis (AD) criterion. In adults, they mainly concern aeroallergens. The inflammation of skin often prevents SPT, but does not exclude the assessment of serous specific immunoglobulin E (sIgE) concentrations. Aim: To assess usefulness of testing AD patients to aeroallergens with SPT and sIgE concentrations, and the correlation of these results and the clinical AD course. Material and methods: In 286 AD patients, t...
For this ‘From the Pages of Allergy Watch’ reviews from several recent issues were selected which review articles about Allergic Skin Diseases, the focus of this issue of the Annals. The first article describes a unique minimally invasive method of skin tape stripping to identify infants with atopic derm atitis who are at increased risk for food allergy. The next study investigates the difference between IgE sensitivity and clinical reactivity to foods in children with atopic dermatitis. The last investigates the impact of UV light exposure and the development of atopic dermatitis in infancy.
Atopic dermatitis (AD) is associated with increased systemic inflammation and cardiovascular risk. While previous studies showed increased inflammatory proteins in the blood of AD patients, detailed comparison among AD patients of different ages is unavailable.
Filaggrin is a major epidermal protein that has been shown to be a key player in the pathogenesis of AD and allergic disease. While filaggrin is a significant genetic risk factor for AD, it is also an important disease modifier in AD. Patients with filaggrin related AD and asthma have more frequent hospital admissions and long-term medication costs. Atopic dermatitis patients with FLG mutations are more frequently affected by reduced health related quality of life when compared to AD patients with wild-type FLG.
Disclosures: E. Guttman-Yassky received board membership from Sanofi Aventis, Regeneron, Stiefel/GlaxoSmithKline, MedImmune, Celgene, Anacor, Leo Pharma, AnaptysBio, Celsus, Dermira, Galderma, Novartis, Pfizer, Vitae, Glenmark, AbbVie, and Asana Biosciences and consultancy fees from Regeneron, Sanofi Aventis, MedImmune, Celgene, Stiefel/GlaxoSmithKline, Celsus, BMS, Amgen, Drais, AbbVie, Anacor, AnaptysBio, Dermira, Galderma, Leo Pharma, Novartis, Pfizer, Vitae, Mitsubishi Tanabe, Eli Lilly, Glenmark, and Asana Biosciences; her institution received grants from Regeneron, Celgene, BMS, Janssen, Dermira, Leo Pharma, Merck, N...
PMID: 31622670 [PubMed - as supplied by publisher]
PMID: 31622669 [PubMed - as supplied by publisher]
Abstract BACKGROUND: Atopic dermatitis (AD) is associated with increased systemic inflammation and cardiovascular risk. While previous studies showed increased inflammatory proteins in the blood of AD patients, detailed comparison among AD patients of different ages is unavailable. OBJECTIVE: To characterize the blood proteomic signature of AD patients as a function of age. Methods We used the OLINK high-throughput proteomic assay to measure serum inflammatory and cardiovascular risk proteins in 71 moderate-to-severe AD patients from three agegroups (18-40 [n=26], 41-60 [n=24],>60 [n=21]), compared to 37 a...
CONCLUSIONS: In the assessed population, there were significantly higher levels among those with positive screening tests and PhInf showed better performance in the identification of sensitized individuals, regardless of age. This is the first study to evaluate Phadiatop and Phadiatop Infant in the same population. PMID: 31601506 [PubMed - as supplied by publisher]
CONCLUSIONS: We found no association of increased skin irritability to SLS with atopic skin diathesis, atopic dermatitis, allergic rhinitis, or allergic asthma in a large patient cohort. It therefore seems that the test of skin irritability with SLS, which is common practice in many centers so far, does not allow to predict the susceptibility to irritant eczematous inflammation in atopic vs. non-atopic individuals. PMID: 31562780 [PubMed - as supplied by publisher]