Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis

Sinonasal inflammation is the result of diverse pathogenetic mechanisms that are poorly understood, but important to elucidate because therapeutic strategies and outcomes of chronic rhinosinusitis (CRS) subtypes differ significantly.1 CRS with nasal polyps has been classically associated with TH2 patterns of inflammation, whereas CRS without nasal polyps has been associated with TH1 inflammatory patterns.1 However, recent research illustrates that these classical patterns are overly simplistic. CRS without nasal polyps may have eosinophilic and TH2 inflammatory signatures, and CRS with nasal polyps may also be associated with noneosinophilic, neutrophilic, and TH1 cytokine patterns (eg, in Asian populations and cystic fibrosis, etc).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research