Glioblastoma-Derived IL-6 Induces Immunosuppressive Peripheral Myeloid Cell PD-L1 and Promotes Tumor Growth.

CONCLUSIONS: Our findings suggest that disruption of IL-6 signaling in GBM reduces local and systemic myeloid-driven immunosuppression and enhances immune-mediated anti-tumor responses against GBM.
PMID: 30824583 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - February 28, 2019 Category: Cancer & Oncology Authors: Lamano JB, Lamano JB, Li YD, DiDomenico JD, Choy W, Veliceasa D, Oyon DE, Fakurnejad S, Ampie L, Kesavabhotla K, Kaur R, Kaur G, Biyashev D, Unruh D, Horbinski C, James CD, Parsa AT, Bloch O Tags: Clin Cancer Res Source Type: research