Activated Extracellular Vesicles as New Therapeutic Targets?

Activated Extracellular Vesicles as New Therapeutic Targets?
Trends Cell Biol. 2019 Feb 27;:
Authors: Languino LR, Hooper DC
Abstract
A recent study by Genschmer et al. (Cell 2019;176:113-126) presents provocative new evidence that extracellular vesicles/exosomes released by activated neutrophils can degrade extracellular proteins. Elastase that is produced by neutrophils both coats the exosomes and is protected by the exosomes from inactivation by α1 antitrypsin, ultimately causing the pathological degradation of extracellular protein fibrils in lung alveoli.
PMID: 30826213 [PubMed - as supplied by publisher]

Source: Trends in Cell Biology - February 26, 2019 Category: Cytology Authors: Languino LR, Hooper DC Tags: Trends Cell Biol Source Type: research